Module 4 PATH 310. Queens University PATH 310

Module 4: Exposures-Based Disorders
Learning Outcomes:
1. Describe the key components that must be integrated to understand
exposure-based disorders.
2. Compare and contrast the contributing disease paradigm
considerations for patients predisposed to cervical cancer versus
Sporadic Creutzfeldt-Jakob disease (sCJD)
3. Identify and explain the general approaches, considerations, and
challenges with diagnostic tests of patients with cervical cancer or
sCJD.
4. Apply your knowledge to a hypothetical exposure-based disease
scenario to describe a potential etiology, mechanism, testing
approach, pathological features, and treatment.
Section 1: Cervical Cancer
Michelle
- 42 years old
- Sexual intercourse had HPV infection
- Current smoker
- Oral contraceptive pills
- Doesn’t encourage condom
- Not been screened for STIs in 5 years
Introduction to Papillomaviruses
HPV belongs to a family of viruses called papillomaviruses. These are small,
non-enveloped, double-stranded DNA (dsDNA) viruses that are speciesspecific and widespread amongst mammals.
Transmission of HPV