Autonomic Nervous System DrugsAutonomic Nervous System Function• Controls cardiac and smooth muscles and glandular secretion• Does everything without consciously thinking about it• Divided into:o Sympathetic: fight or flight Expends energy, increase HR, dilates pupils and bronchi, decreases secretionso Parasympathetic: dominates at rest Conserves energy, decreases HR, increases GI func
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Autonomic Nervous System Drugs
Autonomic Nervous System Function
• Controls cardiac and smooth muscles and glandular secretion
• Does everything without consciously thinking about it
• Divided into:
o Sympathetic: fight or flight
Expends energy, increase HR, dilates pupils and bronchi, decreases secretions
o Parasympathetic: dominates at rest
Conserves energy, decreases HR, increases GI function, constricts pupils
Neurons
• Responsible for autonomic neurotransmission
• Presynaptic: brain to ganglia
• Postsynaptic: ganglia to effector organs
Neurotransmision
• Neurotransmitters (NTs): bind to receptor and cause physiologic change to the cell underneath acting like an
agonist to the tissue which they bind
o Once it does its job it falls off the receptor and is either taken back up by neuron or destroyed and the
effect wears off
• Processes Include:
o Synthesis of NTs
o Packaging/storing of NTs in presynaptic terminals
o Stimulation of presynaptic nerve/release of NT
o Diffusion of NT across synaptic cleft and binding to postsynaptic membrane
o Activation of postsynaptic cell
o Degradation/reuptake of the NT
• Important Neurotransmitters:
o Sympathetic:
Norepinephrine (NE)
Epinephrine (Epi)
Dopamine (DA)
o Parasymp
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