Lecture 1 Hemophilia. Queens University PATH 310

LECTURE 1
ILM before 17th
PATHOLOGY
 Study of disease (pathos = suffering / logia = study of)
 Pathologist > someone who identifies disease by examining fluids, tissues & cells removed from
the body > provide info to clinician
 Pathogenesis > How the disease develops (mechanisms)
DISEASE PARADIGM
 Fill in the paradigm of disease for each one
ETIOLOGY
 Etiology (cause) of disease:
 Genetic vs. environmental (risk factors)
 Has either one or the other
 Known (gene mutation) vs. unknown (risk factors)
 Sometimes its known or unknown
 Complexity of etiology of a disease:
 Hemophilia > monogenic disorder
 Atherosclerosis, VTE, cancer, neurodegenerative
 Multigenetic with environmental risk factors
 No reliable predictive biomarkers (we don’t know who’s going to develop what)